Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
Identifieur interne : 000A02 ( Main/Exploration ); précédent : 000A01; suivant : 000A03Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
Auteurs : Marc Humbert [France] ; Christophe Guignabert [France] ; Sébastien Bonnet [Canada] ; Peter Dorfmüller [France] ; James R. Klinger [États-Unis] ; Mark R. Nicolls [États-Unis] ; Andrea J. Olschewski [Autriche] ; Soni S. Pullamsetti [Allemagne] ; Ralph T. Schermuly [Allemagne] ; Kurt R. Stenmark [États-Unis] ; Marlene Rabinovitch [États-Unis]Source :
- The European Respiratory Journal [ 0903-1936 ] ; 2019.
Abstract
Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (
Url:
DOI: 10.1183/13993003.01887-2018
PubMed: 30545970
PubMed Central: 6351340
Affiliations:
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Paris-Saclay, Le Kremlin-Bicêtre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université Paris-Sud and Université Paris-Saclay, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2">INSERM UMR_S 999, Le Plessis-Robinson, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Plessis-Robinson</wicri:regionArea><wicri:noRegion>Le Plessis-Robinson</wicri:noRegion><wicri:noRegion>Le Plessis-Robinson</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af6">Pathology Dept, Hôpital Marie Lannelongue, Le Plessis-Robinson, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pathology Dept, Hôpital Marie Lannelongue, Le Plessis-Robinson</wicri:regionArea><wicri:noRegion>Le Plessis-Robinson</wicri:noRegion><wicri:noRegion>Le 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Pullamsetti</name><affiliation wicri:level="1"><nlm:aff id="af13">Max Planck Institute for Heart and Lung Research Bad Nauheim, Bad Nauheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Heart and Lung Research Bad Nauheim, Bad Nauheim</wicri:regionArea><wicri:noRegion>Bad Nauheim</wicri:noRegion><wicri:noRegion>Bad Nauheim</wicri:noRegion><wicri:noRegion>Bad Nauheim</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af14">Justus-Liebig University Giessen, Excellence Cluster Cardio Pulmonary Institute (CPI), Giessen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Justus-Liebig University Giessen, Excellence Cluster Cardio Pulmonary Institute (CPI), Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Schermuly, Ralph T" sort="Schermuly, Ralph T" uniqKey="Schermuly R" first="Ralph T." last="Schermuly">Ralph T. Schermuly</name><affiliation wicri:level="1"><nlm:aff id="af15">University of Giessen and Marburg Lung Centre (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio Pulmonary Institute (CPI), Giessen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Giessen and Marburg Lung Centre (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio Pulmonary Institute (CPI), Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Stenmark, Kurt R" sort="Stenmark, Kurt R" uniqKey="Stenmark K" first="Kurt R." last="Stenmark">Kurt R. Stenmark</name><affiliation wicri:level="2"><nlm:aff id="af16">Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado, Denver, CO, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Rabinovitch, Marlene" sort="Rabinovitch, Marlene" uniqKey="Rabinovitch M" first="Marlene" last="Rabinovitch">Marlene Rabinovitch</name><affiliation wicri:level="2"><nlm:aff id="af8">Cardiovascular Institute, Dept of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Institute, Dept of Pediatrics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="af9">Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Stanford University School of Medicine/VA Palo Alto, Palo Alto, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Stanford University School of Medicine/VA Palo Alto, Palo Alto, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="af10">The Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The European Respiratory Journal</title><idno type="ISSN">0903-1936</idno><idno type="eISSN">1399-3003</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (<italic>e.g.</italic> chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fayyaz, Au" uniqKey="Fayyaz A">AU Fayyaz</name></author><author><name sortKey="Edwards, Wd" uniqKey="Edwards W">WD Edwards</name></author><author><name sortKey="Maleszewski, Jj" uniqKey="Maleszewski J">JJ Maleszewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorfmuller, P" uniqKey="Dorfmuller P">P Dorfmuller</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Ghigna, Mr" uniqKey="Ghigna M">MR Ghigna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galambos, C" uniqKey="Galambos C">C Galambos</name></author><author><name sortKey="Sims Lucas, S" uniqKey="Sims Lucas S">S Sims-Lucas</name></author><author><name sortKey="Abman, Sh" 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sort="Dorfmuller, Peter" uniqKey="Dorfmuller P" first="Peter" last="Dorfmüller">Peter Dorfmüller</name><name sortKey="Dorfmuller, Peter" sort="Dorfmuller, Peter" uniqKey="Dorfmuller P" first="Peter" last="Dorfmüller">Peter Dorfmüller</name><name sortKey="Guignabert, Christophe" sort="Guignabert, Christophe" uniqKey="Guignabert C" first="Christophe" last="Guignabert">Christophe Guignabert</name><name sortKey="Guignabert, Christophe" sort="Guignabert, Christophe" uniqKey="Guignabert C" first="Christophe" last="Guignabert">Christophe Guignabert</name><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name></country><country name="Canada"><noRegion><name sortKey="Bonnet, Sebastien" sort="Bonnet, Sebastien" uniqKey="Bonnet S" first="Sébastien" last="Bonnet">Sébastien Bonnet</name></noRegion><name sortKey="Bonnet, Sebastien" sort="Bonnet, Sebastien" uniqKey="Bonnet S" first="Sébastien" last="Bonnet">Sébastien Bonnet</name></country><country name="États-Unis"><region name="Rhode Island"><name sortKey="Klinger, James R" sort="Klinger, James R" uniqKey="Klinger J" first="James R." last="Klinger">James R. Klinger</name></region><name sortKey="Nicolls, Mark R" sort="Nicolls, Mark R" uniqKey="Nicolls M" first="Mark R." last="Nicolls">Mark R. Nicolls</name><name sortKey="Nicolls, Mark R" sort="Nicolls, Mark R" uniqKey="Nicolls M" first="Mark R." last="Nicolls">Mark R. Nicolls</name><name sortKey="Nicolls, Mark R" sort="Nicolls, Mark R" uniqKey="Nicolls M" first="Mark R." last="Nicolls">Mark R. Nicolls</name><name sortKey="Rabinovitch, Marlene" sort="Rabinovitch, Marlene" uniqKey="Rabinovitch M" first="Marlene" last="Rabinovitch">Marlene Rabinovitch</name><name sortKey="Rabinovitch, Marlene" sort="Rabinovitch, Marlene" uniqKey="Rabinovitch M" first="Marlene" last="Rabinovitch">Marlene Rabinovitch</name><name sortKey="Rabinovitch, Marlene" sort="Rabinovitch, Marlene" uniqKey="Rabinovitch M" first="Marlene" last="Rabinovitch">Marlene Rabinovitch</name><name sortKey="Stenmark, Kurt R" sort="Stenmark, Kurt R" uniqKey="Stenmark K" first="Kurt R." last="Stenmark">Kurt R. Stenmark</name></country><country name="Autriche"><noRegion><name sortKey="Olschewski, Andrea J" sort="Olschewski, Andrea J" uniqKey="Olschewski A" first="Andrea J." last="Olschewski">Andrea J. Olschewski</name></noRegion><name sortKey="Olschewski, Andrea J" sort="Olschewski, Andrea J" uniqKey="Olschewski A" first="Andrea J." last="Olschewski">Andrea J. Olschewski</name></country><country name="Allemagne"><noRegion><name sortKey="Pullamsetti, Soni S" sort="Pullamsetti, Soni S" uniqKey="Pullamsetti S" first="Soni S." last="Pullamsetti">Soni S. Pullamsetti</name></noRegion><name sortKey="Pullamsetti, Soni S" sort="Pullamsetti, Soni S" uniqKey="Pullamsetti S" first="Soni S." last="Pullamsetti">Soni S. Pullamsetti</name><name sortKey="Schermuly, Ralph T" sort="Schermuly, Ralph T" uniqKey="Schermuly R" first="Ralph T." last="Schermuly">Ralph T. Schermuly</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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